Giuseppe
Emeritus
Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV. (Virology, abstract, edited)
27. Virology. 2010 Feb 5;397(1):7-13. Epub 2009 Dec 4.
Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV.
Bussmann BM, Reiche S, Bieniek B, Krznaric I, Ackermann F, Jassoy C. - Institute of Virology, Max B?rger Research Center, Universit?t Leipzig, 04103 Leipzig, Germany.
A central, yet unresolved issue in the pathogenesis of HIV disease is the mechanism of antibody perturbation. In this study, HIV-specific memory B-cells were quantified in groups of infected subjects and compared with memory responses to other antigens and antibody titers. HIV-specific memory B-cell responses were vigorous in individuals with CD4(+) T-cell counts >350/microl and weak or undetectable in subjects with CD4(+) T-cell numbers <200/microl. Memory B-cell loss was permanent, because antiretroviral therapy failed to restore HIV-specific memory responses while influenza- and tetanus toxoid-specific memory B-cells remained unaffected or recovered. Antibody titers to Gag strongly correlated with memory B-cell frequencies. In contrast, Env-specific antibodies were maintained in advanced disease despite low or undetectable levels of memory B-cells. These results provide a potential mechanism by which destruction of HIV-specific CD4(+) T-cells affects the humoral immune response against HIV and compromises the ability to maintain an effective antibody response.
Copyright 2009 Elsevier B.V. All rights reserved.
PMID: 19962720 [PubMed - indexed for MEDLINE]
Publication Types:
* Research Support, Non-U.S. Gov't
MeSH Terms:
* Anti-Retroviral Agents/therapeutic use
* Antibodies, Bacterial/blood
* Antibodies, Viral/blood
* B-Lymphocytes/immunology*
* CD4 Lymphocyte Count
* HIV/immunology*
* HIV Antibodies/blood
* HIV Infections/drug therapy
* HIV Infections/immunology*
* Humans
* Immunologic Memory*
* Influenza, Human/immunology
* Tetanus Toxoid/immunology
* env Gene Products, Human Immunodeficiency Virus/immunology
* gag Gene Products, Human Immunodeficiency Virus/immunology
Substances:
* Anti-Retroviral Agents
* Antibodies, Bacterial
* Antibodies, Viral
* HIV Antibodies
* Tetanus Toxoid
* env Gene Products, Human Immunodeficiency Virus
* gag Gene Products, Human Immunodeficiency Virus
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27. Virology. 2010 Feb 5;397(1):7-13. Epub 2009 Dec 4.
Loss of HIV-specific memory B-cells as a potential mechanism for the dysfunction of the humoral immune response against HIV.
Bussmann BM, Reiche S, Bieniek B, Krznaric I, Ackermann F, Jassoy C. - Institute of Virology, Max B?rger Research Center, Universit?t Leipzig, 04103 Leipzig, Germany.
A central, yet unresolved issue in the pathogenesis of HIV disease is the mechanism of antibody perturbation. In this study, HIV-specific memory B-cells were quantified in groups of infected subjects and compared with memory responses to other antigens and antibody titers. HIV-specific memory B-cell responses were vigorous in individuals with CD4(+) T-cell counts >350/microl and weak or undetectable in subjects with CD4(+) T-cell numbers <200/microl. Memory B-cell loss was permanent, because antiretroviral therapy failed to restore HIV-specific memory responses while influenza- and tetanus toxoid-specific memory B-cells remained unaffected or recovered. Antibody titers to Gag strongly correlated with memory B-cell frequencies. In contrast, Env-specific antibodies were maintained in advanced disease despite low or undetectable levels of memory B-cells. These results provide a potential mechanism by which destruction of HIV-specific CD4(+) T-cells affects the humoral immune response against HIV and compromises the ability to maintain an effective antibody response.
Copyright 2009 Elsevier B.V. All rights reserved.
PMID: 19962720 [PubMed - indexed for MEDLINE]
Publication Types:
* Research Support, Non-U.S. Gov't
MeSH Terms:
* Anti-Retroviral Agents/therapeutic use
* Antibodies, Bacterial/blood
* Antibodies, Viral/blood
* B-Lymphocytes/immunology*
* CD4 Lymphocyte Count
* HIV/immunology*
* HIV Antibodies/blood
* HIV Infections/drug therapy
* HIV Infections/immunology*
* Humans
* Immunologic Memory*
* Influenza, Human/immunology
* Tetanus Toxoid/immunology
* env Gene Products, Human Immunodeficiency Virus/immunology
* gag Gene Products, Human Immunodeficiency Virus/immunology
Substances:
* Anti-Retroviral Agents
* Antibodies, Bacterial
* Antibodies, Viral
* HIV Antibodies
* Tetanus Toxoid
* env Gene Products, Human Immunodeficiency Virus
* gag Gene Products, Human Immunodeficiency Virus
-
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