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The severe pathogenicity of alveolar macrophage-depleted ferrets infected with 2009 pandemic H1N1 influenza virus
by: Heui M. Kim, Young M. Kang, Keun B. Ku, Eun H. Park, Jung Yum, Jeong C. Kim, Seo Y. Jin, Joo S. Lee, Hyun S. Kim, Sang H. Seo
Virology (July 2013), doi:10.1016/j.virol.2013.07.006 Key: citeulike:12534142
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Abstract
Alveolar macrophages are critical for controlling 2009H1N1 virus in ferrets. Up to 40% of the infected ferrets depleted of alveolar macrophages died. Higher viral titers were detected in infected alveolar macrophage-depleted ferrets. Chemokines were induced more in infected alveolar macrophage-depleted ferrets. The in vivo role of alveolar macrophages in the infections with 2009 pandemic H1N1 influenza virus is not as yet known. Ferret study shows that alveolar macrophages are critical for lowering the risk of severe outcomes in 2009 pandemic H1N1 influenza virus infections. Up to 40% of the infected ferrets depleted of alveolar macrophages died, with elevated body temperature and major loss of body weight in contrast to infected ferrets not depleted of alveolar macrophages. The higher viral titers in the lungs were detected in infected ferrets depleted of alveolar macrophages than infected ferrets not depleted of alveolar macrophages 5 days after infection. The inflammatory chemokines were induced at greater levels in the lungs of infected ferrets depleted of alveolar macrophages than in those of infected ferrets not depleted of alveolar macrophages. Our study implies that alveolar macrophages are important for controlling the infections of 2009 pandemic H1N1 influenza virus.
http://www.citeulike.org/group/3378/article/12534142
by: Heui M. Kim, Young M. Kang, Keun B. Ku, Eun H. Park, Jung Yum, Jeong C. Kim, Seo Y. Jin, Joo S. Lee, Hyun S. Kim, Sang H. Seo
Virology (July 2013), doi:10.1016/j.virol.2013.07.006 Key: citeulike:12534142
View FullText article
DOI, Pubget, PubMed (Search)
Abstract
Alveolar macrophages are critical for controlling 2009H1N1 virus in ferrets. Up to 40% of the infected ferrets depleted of alveolar macrophages died. Higher viral titers were detected in infected alveolar macrophage-depleted ferrets. Chemokines were induced more in infected alveolar macrophage-depleted ferrets. The in vivo role of alveolar macrophages in the infections with 2009 pandemic H1N1 influenza virus is not as yet known. Ferret study shows that alveolar macrophages are critical for lowering the risk of severe outcomes in 2009 pandemic H1N1 influenza virus infections. Up to 40% of the infected ferrets depleted of alveolar macrophages died, with elevated body temperature and major loss of body weight in contrast to infected ferrets not depleted of alveolar macrophages. The higher viral titers in the lungs were detected in infected ferrets depleted of alveolar macrophages than infected ferrets not depleted of alveolar macrophages 5 days after infection. The inflammatory chemokines were induced at greater levels in the lungs of infected ferrets depleted of alveolar macrophages than in those of infected ferrets not depleted of alveolar macrophages. Our study implies that alveolar macrophages are important for controlling the infections of 2009 pandemic H1N1 influenza virus.
http://www.citeulike.org/group/3378/article/12534142