tetano
Editor, Senior Moderator
Virus Evol
. 2021 Aug 14;7(2):veab069.
doi: 10.1093/ve/veab069. eCollection 2021.
The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the spike protein
Paola Cristina Resende[SUP] 1 [/SUP], Felipe G Naveca[SUP] 2 [/SUP], Roberto D Lins[SUP] 3 [/SUP], Filipe Zimmer Dezordi[SUP] 4 [/SUP], Matheus V F Ferraz[SUP] 3 [/SUP], Emerson G Moreira[SUP] 3 [/SUP], Danilo F Coêlho[SUP] 3 [/SUP], Fernando Couto Motta[SUP] 1 [/SUP], Anna Carolina Dias Paixão[SUP] 1 [/SUP], Luciana Appolinario[SUP] 1 [/SUP], Renata Serrano Lopes[SUP] 1 [/SUP], Ana Carolina da Fonseca Mendonça[SUP] 1 [/SUP], Alice Sampaio Barreto da Rocha[SUP] 1 [/SUP], Valdinete Nascimento[SUP] 2 [/SUP], Victor Souza[SUP] 2 [/SUP], George Silva[SUP] 2 [/SUP], Fernanda Nascimento[SUP] 2 [/SUP], Lidio Gonçalves Lima Neto[SUP] 5 [/SUP], Fabiano Vieira da Silva[SUP] 5 [/SUP], Irina Riediger[SUP] 6 [/SUP], Maria do Carmo Debur[SUP] 6 [/SUP], Anderson Brandao Leite[SUP] 7 [/SUP], Tirza Mattos[SUP] 8 [/SUP], Cristiano Fernandes da Costa[SUP] 9 [/SUP], Felicidade Mota Pereira[SUP] 10 [/SUP], Cliomar Alves Dos Santos[SUP] 11 [/SUP], Darcita Buerger Rovaris[SUP] 12 [/SUP], Sandra Bianchini Fernandes[SUP] 12 [/SUP], Adriano Abbud[SUP] 13 [/SUP], Claudio Sacchi[SUP] 13 [/SUP], Ricardo Khouri[SUP] 14 [/SUP], André Felipe Leal Bernardes[SUP] 15 [/SUP], Edson Delatorre[SUP] 16 [/SUP], Tiago Gräf[SUP] 17 [/SUP], Marilda Mendonça Siqueira[SUP] 1 [/SUP], Gonzalo Bello[SUP] 18 [/SUP], Gabriel L Wallau[SUP] 4 [/SUP]
Affiliations
Abstract
Mutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. Importantly, we detected the community transmission of different P.1 lineages bearing NTD indels ∆69-70 (which can impact several SARS-CoV-2 diagnostic protocols), ∆144 and ins214ANRN, and a new VOI N.10 derived from the B.1.1.33 lineage carrying three NTD deletions (∆141-144, ∆211, and ∆256-258). These findings support that the ongoing widespread transmission of SARS-CoV-2 in Brazil generates new viral lineages that might be more resistant to antibody neutralization than parental variants of concern.
Keywords: COVID-19; SARS-CoV-2; antibody escape; community transmission; pandemics.
. 2021 Aug 14;7(2):veab069.
doi: 10.1093/ve/veab069. eCollection 2021.
The ongoing evolution of variants of concern and interest of SARS-CoV-2 in Brazil revealed by convergent indels in the amino (N)-terminal domain of the spike protein
Paola Cristina Resende[SUP] 1 [/SUP], Felipe G Naveca[SUP] 2 [/SUP], Roberto D Lins[SUP] 3 [/SUP], Filipe Zimmer Dezordi[SUP] 4 [/SUP], Matheus V F Ferraz[SUP] 3 [/SUP], Emerson G Moreira[SUP] 3 [/SUP], Danilo F Coêlho[SUP] 3 [/SUP], Fernando Couto Motta[SUP] 1 [/SUP], Anna Carolina Dias Paixão[SUP] 1 [/SUP], Luciana Appolinario[SUP] 1 [/SUP], Renata Serrano Lopes[SUP] 1 [/SUP], Ana Carolina da Fonseca Mendonça[SUP] 1 [/SUP], Alice Sampaio Barreto da Rocha[SUP] 1 [/SUP], Valdinete Nascimento[SUP] 2 [/SUP], Victor Souza[SUP] 2 [/SUP], George Silva[SUP] 2 [/SUP], Fernanda Nascimento[SUP] 2 [/SUP], Lidio Gonçalves Lima Neto[SUP] 5 [/SUP], Fabiano Vieira da Silva[SUP] 5 [/SUP], Irina Riediger[SUP] 6 [/SUP], Maria do Carmo Debur[SUP] 6 [/SUP], Anderson Brandao Leite[SUP] 7 [/SUP], Tirza Mattos[SUP] 8 [/SUP], Cristiano Fernandes da Costa[SUP] 9 [/SUP], Felicidade Mota Pereira[SUP] 10 [/SUP], Cliomar Alves Dos Santos[SUP] 11 [/SUP], Darcita Buerger Rovaris[SUP] 12 [/SUP], Sandra Bianchini Fernandes[SUP] 12 [/SUP], Adriano Abbud[SUP] 13 [/SUP], Claudio Sacchi[SUP] 13 [/SUP], Ricardo Khouri[SUP] 14 [/SUP], André Felipe Leal Bernardes[SUP] 15 [/SUP], Edson Delatorre[SUP] 16 [/SUP], Tiago Gräf[SUP] 17 [/SUP], Marilda Mendonça Siqueira[SUP] 1 [/SUP], Gonzalo Bello[SUP] 18 [/SUP], Gabriel L Wallau[SUP] 4 [/SUP]
Affiliations
- PMID: 34532067
- PMCID: PMC8438916
- DOI: 10.1093/ve/veab069
Abstract
Mutations at both the receptor-binding domain (RBD) and the amino (N)-terminal domain (NTD) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) glycoprotein can alter its antigenicity and promote immune escape. We identified that SARS-CoV-2 lineages circulating in Brazil with mutations of concern in the RBD independently acquired convergent deletions and insertions in the NTD of the S protein, which altered the NTD antigenic-supersite and other predicted epitopes at this region. Importantly, we detected the community transmission of different P.1 lineages bearing NTD indels ∆69-70 (which can impact several SARS-CoV-2 diagnostic protocols), ∆144 and ins214ANRN, and a new VOI N.10 derived from the B.1.1.33 lineage carrying three NTD deletions (∆141-144, ∆211, and ∆256-258). These findings support that the ongoing widespread transmission of SARS-CoV-2 in Brazil generates new viral lineages that might be more resistant to antibody neutralization than parental variants of concern.
Keywords: COVID-19; SARS-CoV-2; antibody escape; community transmission; pandemics.