tetano
Editor, Senior Moderator
Biomaterials. 2018 Aug 23;183:234-242. doi: 10.1016/j.biomaterials.2018.08.036. [Epub ahead of print]
[h=1]Virus-mimetic polymer nanoparticles displaying hemagglutinin as an adjuvant-free influenza vaccine.[/h] Lee C[SUP]1[/SUP], Jeong J[SUP]1[/SUP], Lee T[SUP]1[/SUP], Zhang W[SUP]2[/SUP], Xu L[SUP]2[/SUP], Choi JE[SUP]3[/SUP], Park JH[SUP]3[/SUP], Song JK[SUP]3[/SUP], Jang S[SUP]4[/SUP], Eom CY[SUP]4[/SUP], Shim K[SUP]5[/SUP], Seong Soo AA[SUP]5[/SUP], Kang YS[SUP]6[/SUP], Kwak M[SUP]7[/SUP], Jeon HJ[SUP]8[/SUP], Go JS[SUP]8[/SUP], Suh YD[SUP]9[/SUP], Jin JO[SUP]10[/SUP], Paik HJ[SUP]11[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The generation of virus-mimetic nanoparticles has received much attention in developing a new vaccine for overcoming the limitations of current vaccines. Thus, a method, encompassing most viral features for their size, hydrophobic domain and antigen display, would represent a meaningful direction for the vaccine development. In the present study, a polymer-templated protein nanoball with direction oriented hemagglutinin1 on its surface (H1-NB) was prepared as a new influenza vaccine, exhibiting most of the viral features. Moreover, the concentrations of antigen on the particle surface were controlled, and its effect on immunogenicity was estimated by in vivo studies. Finally, H1-NB efficiently promoted H1-specific immune activation and cross-protective activities, which consequently prevented H1N1 infections in mice.
[h=4]KEYWORDS:[/h] Antigen-specific immune activation; Influenza vaccine; Protein-polymer nanoparticle; Virus-mimicking; in situ method
PMID: 30176403 DOI: 10.1016/j.biomaterials.2018.08.036
[h=1]Virus-mimetic polymer nanoparticles displaying hemagglutinin as an adjuvant-free influenza vaccine.[/h] Lee C[SUP]1[/SUP], Jeong J[SUP]1[/SUP], Lee T[SUP]1[/SUP], Zhang W[SUP]2[/SUP], Xu L[SUP]2[/SUP], Choi JE[SUP]3[/SUP], Park JH[SUP]3[/SUP], Song JK[SUP]3[/SUP], Jang S[SUP]4[/SUP], Eom CY[SUP]4[/SUP], Shim K[SUP]5[/SUP], Seong Soo AA[SUP]5[/SUP], Kang YS[SUP]6[/SUP], Kwak M[SUP]7[/SUP], Jeon HJ[SUP]8[/SUP], Go JS[SUP]8[/SUP], Suh YD[SUP]9[/SUP], Jin JO[SUP]10[/SUP], Paik HJ[SUP]11[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The generation of virus-mimetic nanoparticles has received much attention in developing a new vaccine for overcoming the limitations of current vaccines. Thus, a method, encompassing most viral features for their size, hydrophobic domain and antigen display, would represent a meaningful direction for the vaccine development. In the present study, a polymer-templated protein nanoball with direction oriented hemagglutinin1 on its surface (H1-NB) was prepared as a new influenza vaccine, exhibiting most of the viral features. Moreover, the concentrations of antigen on the particle surface were controlled, and its effect on immunogenicity was estimated by in vivo studies. Finally, H1-NB efficiently promoted H1-specific immune activation and cross-protective activities, which consequently prevented H1N1 infections in mice.
[h=4]KEYWORDS:[/h] Antigen-specific immune activation; Influenza vaccine; Protein-polymer nanoparticle; Virus-mimicking; in situ method
PMID: 30176403 DOI: 10.1016/j.biomaterials.2018.08.036