tetano
Editor, Senior Moderator
Viruses
. 2022 Feb 14;14(2):387.
doi: 10.3390/v14020387.
A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines
Naru Zhang[SUP] 1 [/SUP], Kangchen Li[SUP] 1 [/SUP], Zezhong Liu[SUP] 2 [/SUP], Kutty Selva Nandakumar[SUP] 3 [/SUP], Shibo Jiang[SUP] 2 [/SUP]
Affiliations
Abstract
Several countries have made unremitting efforts to develop an optimal vaccine in the fight against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the increasing occurrence of SARS-CoV-2 variants, current vaccines show decreased neutralizing activities, especially towards the Omicron variant. In this context, adding appropriate adjuvants to COVID-19 vaccines can substantially reduce the number of required doses and improve efficacy or cross-neutralizing protection. We mainly focus on research progress and achievements associated with adjuvanted COVID-19 subunit and inactivated vaccines. We further compare the advantages and disadvantages of different adjuvant formulations in order to provide a scientific reference for designing an effective strategy for future vaccine development.
Keywords: COVID-19; SARS-CoV-2; adjuvant; vaccine; variants.
. 2022 Feb 14;14(2):387.
doi: 10.3390/v14020387.
A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines
Naru Zhang[SUP] 1 [/SUP], Kangchen Li[SUP] 1 [/SUP], Zezhong Liu[SUP] 2 [/SUP], Kutty Selva Nandakumar[SUP] 3 [/SUP], Shibo Jiang[SUP] 2 [/SUP]
Affiliations
- PMID: 35215980
- DOI: 10.3390/v14020387
Abstract
Several countries have made unremitting efforts to develop an optimal vaccine in the fight against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the increasing occurrence of SARS-CoV-2 variants, current vaccines show decreased neutralizing activities, especially towards the Omicron variant. In this context, adding appropriate adjuvants to COVID-19 vaccines can substantially reduce the number of required doses and improve efficacy or cross-neutralizing protection. We mainly focus on research progress and achievements associated with adjuvanted COVID-19 subunit and inactivated vaccines. We further compare the advantages and disadvantages of different adjuvant formulations in order to provide a scientific reference for designing an effective strategy for future vaccine development.
Keywords: COVID-19; SARS-CoV-2; adjuvant; vaccine; variants.