tetano
Editor, Senior Moderator
Viruses
. 2021 Dec 15;13(12):2517.
doi: 10.3390/v13122517.
Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury
Guillaume Favre[SUP] 1 [/SUP], Sara Mazzetti[SUP] 2 [/SUP], Carole Gengler[SUP] 3 [/SUP], Claire Bertelli[SUP] 4 [/SUP], Juliane Schneider[SUP] 5 [/SUP], Bernard Laubscher[SUP] 2 6 [/SUP], Romina Capoccia[SUP] 7 [/SUP], Fatemeh Pakniyat[SUP] 7 [/SUP], Inès Ben Jazia[SUP] 7 [/SUP], Béatrice Eggel-Hort[SUP] 8 [/SUP], Laurence de Leval[SUP] 3 [/SUP], Léo Pomar[SUP] 1 9 [/SUP], Gilbert Greub[SUP] 4 10 [/SUP], David Baud[SUP] 1 [/SUP], Eric Giannoni[SUP] 5 [/SUP]
Affiliations
Abstract
Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.
Keywords: COVID-19; MRI; SARS-CoV-2; brain injury; fetal movements; neurosonography; perinatal; placental.
. 2021 Dec 15;13(12):2517.
doi: 10.3390/v13122517.
Decreased Fetal Movements: A Sign of Placental SARS-CoV-2 Infection with Perinatal Brain Injury
Guillaume Favre[SUP] 1 [/SUP], Sara Mazzetti[SUP] 2 [/SUP], Carole Gengler[SUP] 3 [/SUP], Claire Bertelli[SUP] 4 [/SUP], Juliane Schneider[SUP] 5 [/SUP], Bernard Laubscher[SUP] 2 6 [/SUP], Romina Capoccia[SUP] 7 [/SUP], Fatemeh Pakniyat[SUP] 7 [/SUP], Inès Ben Jazia[SUP] 7 [/SUP], Béatrice Eggel-Hort[SUP] 8 [/SUP], Laurence de Leval[SUP] 3 [/SUP], Léo Pomar[SUP] 1 9 [/SUP], Gilbert Greub[SUP] 4 10 [/SUP], David Baud[SUP] 1 [/SUP], Eric Giannoni[SUP] 5 [/SUP]
Affiliations
- PMID: 34960786
- DOI: 10.3390/v13122517
Abstract
Neonatal COVID-19 is rare and mainly results from postnatal transmission. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), however, can infect the placenta and compromise its function. We present two cases of decreased fetal movements and abnormal fetal heart rhythm 5 days after mild maternal COVID-19, requiring emergency caesarean section at 29 + 3 and 32 + 1 weeks of gestation, and leading to brain injury. Placental examination revealed extensive and multifocal chronic intervillositis, with intense cytoplasmic positivity for SARS-CoV-2 spike antibody and SARS-CoV-2 detection by RT-qPCR. Vertical transmission was confirmed in one case, and both neonates developed extensive cystic peri-ventricular leukomalacia.
Keywords: COVID-19; MRI; SARS-CoV-2; brain injury; fetal movements; neurosonography; perinatal; placental.