tetano
Editor, Senior Moderator
Viruses
. 2021 Oct 19;13(10):2104.
doi: 10.3390/v13102104.
Near-Complete Genome of SARS-CoV-2 Delta (AY.3) Variant Identified in a Dog in Kansas, USA
Tyler Doerksen[SUP] 1 [/SUP], Andrea Lu[SUP] 1 [/SUP], Lance Noll[SUP] 1 [/SUP], Kelli Almes[SUP] 1 [/SUP], Jianfa Bai[SUP] 1 [/SUP], David Upchurch[SUP] 2 [/SUP], Rachel Palinski[SUP] 1 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) descriptions of infection and transmission have been increasing in companion animals in the past year. Although canine susceptibility is generally considered low, their role in the COVID-19 disease cycle remains unknown. In this study, we detected and sequenced a delta variant (AY.3) from a 12-year-old Collie living with owners that previously tested positive for SARS-CoV-2. It is unclear if the dogs' symptoms were related to SARS-CoV-2 infection or underlying conditions. The whole genome sequence obtained from the dog sample had several unique consensus level changes not previously identified in a SARS-CoV-2 genome that may play a role in the rapid adaptation from humans to dogs. Within the spike coding region, 5/7 of the subconsensus variants identified in the dog sequence were also identified in the closest in-house human reference case. Taken together, the whole genome sequence, and phylogenetic and subconsensus variant analyses indicate the virus infecting the animal originated from a local outbreak cluster. The results of these analyses emphasize the importance of rapid detection and characterization of SARS-CoV-2 variants of concern in companion animals.
Keywords: AY.3; COVID-19; SARS-CoV-2; canine; delta variant; dog.
. 2021 Oct 19;13(10):2104.
doi: 10.3390/v13102104.
Near-Complete Genome of SARS-CoV-2 Delta (AY.3) Variant Identified in a Dog in Kansas, USA
Tyler Doerksen[SUP] 1 [/SUP], Andrea Lu[SUP] 1 [/SUP], Lance Noll[SUP] 1 [/SUP], Kelli Almes[SUP] 1 [/SUP], Jianfa Bai[SUP] 1 [/SUP], David Upchurch[SUP] 2 [/SUP], Rachel Palinski[SUP] 1 [/SUP]
Affiliations
- PMID: 34696534
- DOI: 10.3390/v13102104
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) descriptions of infection and transmission have been increasing in companion animals in the past year. Although canine susceptibility is generally considered low, their role in the COVID-19 disease cycle remains unknown. In this study, we detected and sequenced a delta variant (AY.3) from a 12-year-old Collie living with owners that previously tested positive for SARS-CoV-2. It is unclear if the dogs' symptoms were related to SARS-CoV-2 infection or underlying conditions. The whole genome sequence obtained from the dog sample had several unique consensus level changes not previously identified in a SARS-CoV-2 genome that may play a role in the rapid adaptation from humans to dogs. Within the spike coding region, 5/7 of the subconsensus variants identified in the dog sequence were also identified in the closest in-house human reference case. Taken together, the whole genome sequence, and phylogenetic and subconsensus variant analyses indicate the virus infecting the animal originated from a local outbreak cluster. The results of these analyses emphasize the importance of rapid detection and characterization of SARS-CoV-2 variants of concern in companion animals.
Keywords: AY.3; COVID-19; SARS-CoV-2; canine; delta variant; dog.