tetano
Editor, Senior Moderator
Viruses
. 2021 Jun 10;13(6):1115.
doi: 10.3390/v13061115.
The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral Structure, Biological Functions, and a Potential Target for Drug or Vaccine Mitigation
Zhihua Bai[SUP] 1 2 [/SUP], Ying Cao[SUP] 1 3 [/SUP], Wenjun Liu[SUP] 1 2 4 [/SUP], Jing Li[SUP] 1 2 [/SUP]
Affiliations
Abstract
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world is still expanding. Thus, there is an urgent need to better understand this novel virus and find a way to control its spread. Like other coronaviruses, the nucleocapsid (N) protein is one of the most crucial structural components of SARS-CoV-2. This protein shares 90% homology with the severe acute respiratory syndrome coronavirus N protein, implying functional significance. Based on the evolutionary conservation of the N protein in coronavirus, we reviewed the currently available knowledge regarding the SARS-CoV-2 N protein in terms of structure, biological functions, and clinical application as a drug target or vaccine candidate.
Keywords: SARS-CoV-2; biological function; nucleocapsid protein; structure; vaccine.
. 2021 Jun 10;13(6):1115.
doi: 10.3390/v13061115.
The SARS-CoV-2 Nucleocapsid Protein and Its Role in Viral Structure, Biological Functions, and a Potential Target for Drug or Vaccine Mitigation
Zhihua Bai[SUP] 1 2 [/SUP], Ying Cao[SUP] 1 3 [/SUP], Wenjun Liu[SUP] 1 2 4 [/SUP], Jing Li[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34200602
- DOI: 10.3390/v13061115
Abstract
The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the world is still expanding. Thus, there is an urgent need to better understand this novel virus and find a way to control its spread. Like other coronaviruses, the nucleocapsid (N) protein is one of the most crucial structural components of SARS-CoV-2. This protein shares 90% homology with the severe acute respiratory syndrome coronavirus N protein, implying functional significance. Based on the evolutionary conservation of the N protein in coronavirus, we reviewed the currently available knowledge regarding the SARS-CoV-2 N protein in terms of structure, biological functions, and clinical application as a drug target or vaccine candidate.
Keywords: SARS-CoV-2; biological function; nucleocapsid protein; structure; vaccine.