tetano
Editor, Senior Moderator
Wien Med Wochenschr
. 2022 Feb 8;1-7.
doi: 10.1007/s10354-022-00914-5. Online ahead of print.
Chest CT severity score: assessment of COVID‑19 severity and short-term prognosis in hospitalized Iranian patients
Alireza Aziz-Ahari[SUP] 1 [/SUP], Mahsa Keyhanian[SUP] 1 [/SUP], Setareh Mamishi[SUP] 2 3 [/SUP], Shima Mahmoudi[SUP] 2 3 [/SUP], Ebrahim Ebrahimi Bastani[SUP] 1 [/SUP], Fatemeh Asadi[SUP] 4 [/SUP], Mohammadreza Khaleghi[SUP] 5 6 [/SUP]
Affiliations
Abstract
Background: The aim of this study was to evaluate the value of chest computed tomography (CT) severity score in the assessment of coronavirus disease 2019 (COVID‑19) severity and short-term prognosis.
Methods: In this cross-sectional study, we evaluated all patients who were referred to our university hospital, from 21 May 2020 to 22 June 2020 with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription-polymerase chain reaction (RT-PCR) test. The patients suspected of having other respiratory diseases including influenza, according to an infectious disease specialist, and those without chest CT scan were excluded. A chest CT was obtained for all patients between days 4 and 7 days after symptom onset. Chest CT severity score was also calculated based on the degree of involvement of the lung lobes as 0%, (0 points), 1-25% (1 point), 26-50% (2 points), 51-75% (3 points), and 76-100% (4 points). The CT severity score was quantified by summing the 5 lobe indices (range 0-20). The ROC curve analysis was performed for the clinical value of CT scores in distinguishing the patients based on the severity of disease (mild/moderate group versus severe group), ICU admission, intubation requirement, and mortality.
Results: Of the 148 patients included, 93 patients recovered, while 55 patients died (mortality rate 37%). The area under the curve of CT score for discriminating of recovered patients from deceased individuals was 0.726, and the optimal CT score threshold was 15.5 with 61.8% sensitivity and 76.3% specificity. The best CT score cut-off for discriminating of patients based on the severity of disease was 12.5 with 68.3% sensitivity and 72.7% specificity. In addition, with CT score cut-off of 15.5, sensitivities of 70.8% and 51.6% and specificities of 78% and 72.6% were observed for intubation and ICU admission, respectively.
Conclusion: CT scan and semiquantitative scoring method could be beneficial and applicable in predicting the patient's condition.
Keywords: Computed tomography scan; Computed tomography severity score; Coronavirus disease 2019; Mortality; Severity.
. 2022 Feb 8;1-7.
doi: 10.1007/s10354-022-00914-5. Online ahead of print.
Chest CT severity score: assessment of COVID‑19 severity and short-term prognosis in hospitalized Iranian patients
Alireza Aziz-Ahari[SUP] 1 [/SUP], Mahsa Keyhanian[SUP] 1 [/SUP], Setareh Mamishi[SUP] 2 3 [/SUP], Shima Mahmoudi[SUP] 2 3 [/SUP], Ebrahim Ebrahimi Bastani[SUP] 1 [/SUP], Fatemeh Asadi[SUP] 4 [/SUP], Mohammadreza Khaleghi[SUP] 5 6 [/SUP]
Affiliations
- PMID: 35133531
- PMCID: PMC8824536
- DOI: 10.1007/s10354-022-00914-5
Abstract
Background: The aim of this study was to evaluate the value of chest computed tomography (CT) severity score in the assessment of coronavirus disease 2019 (COVID‑19) severity and short-term prognosis.
Methods: In this cross-sectional study, we evaluated all patients who were referred to our university hospital, from 21 May 2020 to 22 June 2020 with positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription-polymerase chain reaction (RT-PCR) test. The patients suspected of having other respiratory diseases including influenza, according to an infectious disease specialist, and those without chest CT scan were excluded. A chest CT was obtained for all patients between days 4 and 7 days after symptom onset. Chest CT severity score was also calculated based on the degree of involvement of the lung lobes as 0%, (0 points), 1-25% (1 point), 26-50% (2 points), 51-75% (3 points), and 76-100% (4 points). The CT severity score was quantified by summing the 5 lobe indices (range 0-20). The ROC curve analysis was performed for the clinical value of CT scores in distinguishing the patients based on the severity of disease (mild/moderate group versus severe group), ICU admission, intubation requirement, and mortality.
Results: Of the 148 patients included, 93 patients recovered, while 55 patients died (mortality rate 37%). The area under the curve of CT score for discriminating of recovered patients from deceased individuals was 0.726, and the optimal CT score threshold was 15.5 with 61.8% sensitivity and 76.3% specificity. The best CT score cut-off for discriminating of patients based on the severity of disease was 12.5 with 68.3% sensitivity and 72.7% specificity. In addition, with CT score cut-off of 15.5, sensitivities of 70.8% and 51.6% and specificities of 78% and 72.6% were observed for intubation and ICU admission, respectively.
Conclusion: CT scan and semiquantitative scoring method could be beneficial and applicable in predicting the patient's condition.
Keywords: Computed tomography scan; Computed tomography severity score; Coronavirus disease 2019; Mortality; Severity.