tetano
Editor, Senior Moderator
World J Clin Cases
. 2022 Apr 6;10(10):3047-3059.
doi: 10.12998/wjcc.v10.i10.3047.
Dose-response relationship between risk factors and incidence of COVID-19 in 325 hospitalized patients: A multicenter retrospective cohort study
Sheng-Chao Zhao[SUP] 1 [/SUP], Xian-Qiang Yu[SUP] 2 [/SUP], Xue-Feng Lai[SUP] 3 [/SUP], Rui Duan[SUP] 4 [/SUP], De-Liang Guo[SUP] 5 [/SUP], Qian Zhu[SUP] 6 [/SUP]
Affiliations
Abstract
Background: The epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients have been widely reported, but the assessment of dose-response relationships and risk factors for mortality and severe cases and clinical outcomes remain unclear.
Aim: To determine the dose-response relationship between risk factors and incidence of COVID-19.
Methods: In this retrospective, multicenter cohort study, we included patients with confirmed COVID-19 infection who had been discharged or had died by February 6, 2020. We used multivariable logistic regression and Cox proportional hazard models to determine the dose-response relationship between risk factors and incidence of COVID-19.
Results: It clarified that increasing risk of in-hospital death were associated with older age (HR: 1.04, 95%CI: 1.01-1.09), higher lactate dehydrogenase [HR: 1.04, 95% confidence interval (CI): 1.01-1.10], C-reactive protein (HR: 1.10, 95%CI: 1.01-1.23), and procalcitonin (natural log-transformed HR: 1.88, 95%CI: 1.22-2.88), and D-dimer greater than 1 μg/mL at admission (natural log transformed HR: 1.63, 95%CI: 1.03-2.58) by multivariable regression. D-dimer and procalcitonin were logarithmically correlated with COVID-19 mortality risk, while there was a linear dose-response correlation between age, lactate dehydrogenase, D-dimer and procalcitonin, independent of established risk factors.
Conclusion: Higher lactate dehydrogenase, D-dimer, and procalcitonin levels were independently associated with a dose-response increased risk of COVID-19 mortality.
Keywords: Coronavirus disease 2019; Dose-response relationship; Incidence; Prognosis; Risk factor
. 2022 Apr 6;10(10):3047-3059.
doi: 10.12998/wjcc.v10.i10.3047.
Dose-response relationship between risk factors and incidence of COVID-19 in 325 hospitalized patients: A multicenter retrospective cohort study
Sheng-Chao Zhao[SUP] 1 [/SUP], Xian-Qiang Yu[SUP] 2 [/SUP], Xue-Feng Lai[SUP] 3 [/SUP], Rui Duan[SUP] 4 [/SUP], De-Liang Guo[SUP] 5 [/SUP], Qian Zhu[SUP] 6 [/SUP]
Affiliations
- PMID: 35647111
- PMCID: PMC9082690
- DOI: 10.12998/wjcc.v10.i10.3047
Abstract
Background: The epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19) patients have been widely reported, but the assessment of dose-response relationships and risk factors for mortality and severe cases and clinical outcomes remain unclear.
Aim: To determine the dose-response relationship between risk factors and incidence of COVID-19.
Methods: In this retrospective, multicenter cohort study, we included patients with confirmed COVID-19 infection who had been discharged or had died by February 6, 2020. We used multivariable logistic regression and Cox proportional hazard models to determine the dose-response relationship between risk factors and incidence of COVID-19.
Results: It clarified that increasing risk of in-hospital death were associated with older age (HR: 1.04, 95%CI: 1.01-1.09), higher lactate dehydrogenase [HR: 1.04, 95% confidence interval (CI): 1.01-1.10], C-reactive protein (HR: 1.10, 95%CI: 1.01-1.23), and procalcitonin (natural log-transformed HR: 1.88, 95%CI: 1.22-2.88), and D-dimer greater than 1 μg/mL at admission (natural log transformed HR: 1.63, 95%CI: 1.03-2.58) by multivariable regression. D-dimer and procalcitonin were logarithmically correlated with COVID-19 mortality risk, while there was a linear dose-response correlation between age, lactate dehydrogenase, D-dimer and procalcitonin, independent of established risk factors.
Conclusion: Higher lactate dehydrogenase, D-dimer, and procalcitonin levels were independently associated with a dose-response increased risk of COVID-19 mortality.
Keywords: Coronavirus disease 2019; Dose-response relationship; Incidence; Prognosis; Risk factor