tetano
Editor, Senior Moderator
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
. 2020 Jul;32(7):774-778.
doi: 10.3760/cma.j.cn121430-20200331-00417.
[Correlation between hyponatremia and the severity of coronavirus disease 2019]
[Article in Chinese]
Weidai Zhang[SUP] 1 [/SUP], Senrong Lu[SUP] 2 [/SUP], Mianfeng Zhang[SUP] 3 [/SUP], Hongbin Zheng[SUP] 4 [/SUP], Yuhan Huang[SUP] 5 [/SUP], Suzhi Chen[SUP] 3 [/SUP], Huizhong Kang[SUP] 6 [/SUP], Suwu Wu[SUP] 3 [/SUP]
Affiliations
Abstract
Objective: To investigate the correlation between hyponatremia and the severity of coronavirus disease 2019 (COVID-19).
Methods: Clinical data of 12 patients with COVID-19 admitted to Shantou Central Hospital from January 23 to February 5 in 2020 were retrospectively analyzed, including gender, age, symptoms, lab test and clinical outcomes, to analyze the change trend of blood Na[SUP]+[/SUP] level in the patients with COVID-19.
Results: Among the 12 patients with COVID-19, there were 8 males and 4 females with the mean age of (38.0?16.3) years old, most of them were admitted to the hospital with cough and/or fever. All patients had a positive nucleic acid test for 2019 novel coronavirus (2019-nCoV), and were discharged after clinical treatment with oxygen therapy, antiviral, antibacterial, anti-inflammatory, and nutritional support. All patients were of ordinary type when they were admitted to the hospital. Among them, 1 patient turned into a severe case during the course of the disease, and 1 patient showed a tendency to become severe case. It was found that 10 patients without severe conversion had an average blood Na[SUP]+[/SUP] of (138.3?1.3) mmol/L at admission, and the lowest blood Na[SUP]+[/SUP] during the course of disease was (135.9?3.1) mmol/L. However, 2 patients who became severe and had a tendency to become severe disease (Na[SUP]+[/SUP] levels at admission were 140.0 mmol/L and 138.0 mmol/L, respectively) experienced hyponatremia during the course of the disease (the lowest blood Na[SUP]+[/SUP] levels were 129.0 mmol/L and 122.0 mmol/L). Further analysis showed that the lower serum Na[SUP]+[/SUP] level, the higher level of white blood cell count (WBC) and C-reactive protein (CRP), but serum Na[SUP]+[/SUP] level was consistent with the change trend of lymphocytes, suggesting that hyponatremia was closely correlated with severe inflammation reaction.
Conclusions: Serum Na[SUP]+[/SUP] showed decreasing tendency during the development of COVID-19, and hyponatremia was closely related to the severity of COVID-19. It was necessary to pay great attention to the change trend of blood Na[SUP]+[/SUP] level. However, further research was needed to obtain more reliable conclusions and explorer the pathophysiological mechanisms.
. 2020 Jul;32(7):774-778.
doi: 10.3760/cma.j.cn121430-20200331-00417.
[Correlation between hyponatremia and the severity of coronavirus disease 2019]
[Article in Chinese]
Weidai Zhang[SUP] 1 [/SUP], Senrong Lu[SUP] 2 [/SUP], Mianfeng Zhang[SUP] 3 [/SUP], Hongbin Zheng[SUP] 4 [/SUP], Yuhan Huang[SUP] 5 [/SUP], Suzhi Chen[SUP] 3 [/SUP], Huizhong Kang[SUP] 6 [/SUP], Suwu Wu[SUP] 3 [/SUP]
Affiliations
- PMID: 32788008
- DOI: 10.3760/cma.j.cn121430-20200331-00417
Abstract
Objective: To investigate the correlation between hyponatremia and the severity of coronavirus disease 2019 (COVID-19).
Methods: Clinical data of 12 patients with COVID-19 admitted to Shantou Central Hospital from January 23 to February 5 in 2020 were retrospectively analyzed, including gender, age, symptoms, lab test and clinical outcomes, to analyze the change trend of blood Na[SUP]+[/SUP] level in the patients with COVID-19.
Results: Among the 12 patients with COVID-19, there were 8 males and 4 females with the mean age of (38.0?16.3) years old, most of them were admitted to the hospital with cough and/or fever. All patients had a positive nucleic acid test for 2019 novel coronavirus (2019-nCoV), and were discharged after clinical treatment with oxygen therapy, antiviral, antibacterial, anti-inflammatory, and nutritional support. All patients were of ordinary type when they were admitted to the hospital. Among them, 1 patient turned into a severe case during the course of the disease, and 1 patient showed a tendency to become severe case. It was found that 10 patients without severe conversion had an average blood Na[SUP]+[/SUP] of (138.3?1.3) mmol/L at admission, and the lowest blood Na[SUP]+[/SUP] during the course of disease was (135.9?3.1) mmol/L. However, 2 patients who became severe and had a tendency to become severe disease (Na[SUP]+[/SUP] levels at admission were 140.0 mmol/L and 138.0 mmol/L, respectively) experienced hyponatremia during the course of the disease (the lowest blood Na[SUP]+[/SUP] levels were 129.0 mmol/L and 122.0 mmol/L). Further analysis showed that the lower serum Na[SUP]+[/SUP] level, the higher level of white blood cell count (WBC) and C-reactive protein (CRP), but serum Na[SUP]+[/SUP] level was consistent with the change trend of lymphocytes, suggesting that hyponatremia was closely correlated with severe inflammation reaction.
Conclusions: Serum Na[SUP]+[/SUP] showed decreasing tendency during the development of COVID-19, and hyponatremia was closely related to the severity of COVID-19. It was necessary to pay great attention to the change trend of blood Na[SUP]+[/SUP] level. However, further research was needed to obtain more reliable conclusions and explorer the pathophysiological mechanisms.