tetano
Editor, Senior Moderator
Zool Res
. 2021 May 18;42(3):335-338.
doi: 10.24272/j.issn.2095-8137.2021.088.
Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice
Teng-Yu Zhu[SUP] 1 2 3 4 [/SUP], Huan Qiu[SUP] 2 3 [/SUP], Qi-Qi Cao[SUP] 1 [/SUP], Zi-Lei Duan[SUP] 2 4 [/SUP], Feng-Liang Liu[SUP] 2 [/SUP], Tian-Zhang Song[SUP] 2 [/SUP], Yang Liu[SUP] 2 3 [/SUP], Ya-Qun Fang[SUP] 2 4 [/SUP], Guang-Ming Wu[SUP] 5 [/SUP], Yong-Tang Zheng[SUP] 2 4 [/SUP], Wen-Jun Ding[SUP] 6 [/SUP], Ren Lai[SUP] 1 2 4 [/SUP], Lin Jin[SUP] 2 7 [/SUP]
Affiliations
Abstract
in English, Chinese
The global outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as of 8 May 2021, has surpassed 150 700 000 infections and 3 279 000 deaths worldwide. Evidence indicates that SARS-CoV-2 RNA can be detected on particulate matter (PM), and COVID-19 cases are correlated with levels of air pollutants. However, the mechanisms of PM involvement in the spread of SARS-CoV-2 remain poorly understood. Here, we found that PM exposure increased the expression level of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in several epithelial cells and increased the adsorption of the SARS-CoV-2 spike protein. Instillation of PM in a hACE2 mouse model significantly increased the expression of ACE2 and Tmprss2 and viral replication in the lungs. Furthermore, PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 mice. In conclusion, our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic.
Keywords: COVID-19; Epidemic risk; Particulate matter; SARS-CoV-2 entry factor; hACE2 mice.
. 2021 May 18;42(3):335-338.
doi: 10.24272/j.issn.2095-8137.2021.088.
Particulate matter exposure exacerbates susceptibility to SARS-CoV-2 infection in humanized ACE2 mice
Teng-Yu Zhu[SUP] 1 2 3 4 [/SUP], Huan Qiu[SUP] 2 3 [/SUP], Qi-Qi Cao[SUP] 1 [/SUP], Zi-Lei Duan[SUP] 2 4 [/SUP], Feng-Liang Liu[SUP] 2 [/SUP], Tian-Zhang Song[SUP] 2 [/SUP], Yang Liu[SUP] 2 3 [/SUP], Ya-Qun Fang[SUP] 2 4 [/SUP], Guang-Ming Wu[SUP] 5 [/SUP], Yong-Tang Zheng[SUP] 2 4 [/SUP], Wen-Jun Ding[SUP] 6 [/SUP], Ren Lai[SUP] 1 2 4 [/SUP], Lin Jin[SUP] 2 7 [/SUP]
Affiliations
- PMID: 33998180
- DOI: 10.24272/j.issn.2095-8137.2021.088
Abstract
in English, Chinese
The global outbreak of coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as of 8 May 2021, has surpassed 150 700 000 infections and 3 279 000 deaths worldwide. Evidence indicates that SARS-CoV-2 RNA can be detected on particulate matter (PM), and COVID-19 cases are correlated with levels of air pollutants. However, the mechanisms of PM involvement in the spread of SARS-CoV-2 remain poorly understood. Here, we found that PM exposure increased the expression level of angiotensin-converting enzyme 2 (ACE2) and transmembrane serine protease 2 (TMPRSS2) in several epithelial cells and increased the adsorption of the SARS-CoV-2 spike protein. Instillation of PM in a hACE2 mouse model significantly increased the expression of ACE2 and Tmprss2 and viral replication in the lungs. Furthermore, PM exacerbated the pulmonary lesions caused by SARS-CoV-2 infection in the hACE2 mice. In conclusion, our study demonstrated that PM is an epidemiological factor of COVID-19, emphasizing the necessity of wearing anti-PM masks to cope with this global pandemic.
Keywords: COVID-19; Epidemic risk; Particulate matter; SARS-CoV-2 entry factor; hACE2 mice.